← ClaudeAtlas

interpro-databaselisted

Identify domains, families, and sites in proteins; find all proteins in a family or sharing a domain; explore species distribution for a domain; annotate genomes with protein families and GO terms. InterPro combines 14 databases (e.g., Pfam, CDD) into one searchable resource. InterPro-N significantly expands annotation and sequence coverage with deep learning. Includes domain architecture (IDA) search.
BeyondTheProtocol/polaris · ★ 30 · AI & Automation · score 72
Install: claude install-skill BeyondTheProtocol/polaris
# InterPro Database Access ## Prerequisites 1. **`uv`**: Read the `uv` skill and follow its Setup instructions to ensure `uv` is installed and on PATH. 2. **User Notification**: If .licenses/interpro_database_LICENSE.txt does not already exist in the workspace root directory then (1) prominently notify the user to check the terms at https://www.ebi.ac.uk/interpro/ and https://www.ebi.ac.uk/about/terms-of-use/, then (2) create the file recording the notification text and timestamp. ## Overview InterPro combines signatures from multiple, diverse databases into a single searchable resource, reducing redundancy and helping users interpret their sequence analysis results. By uniting these member databases (e.g., Pfam, CDD, SMART), InterPro capitalises on their individual strengths to produce a powerful diagnostic tool and integrated resource. Use `interpro-database` to: - Identify what domains, families, and sites are found in a particular protein. - Identify all proteins that belong to a protein family or contain a particular domain, even when the names and activities of the proteins are highly variable. - Examine the species in which a particular protein family or domain is found. - Annotate genomes with protein family information and Gene Ontology (GO) terms. This skill provides a robust utility, `interpro_client.py`, to interact with the InterPro API seamlessly. It natively handles rate limiting (HTTP 429), background query