Discover the best agent skills

The curated index for production-quality Claude ecosystem skills.

119,840+ analyzed · 100,060 indexed · 10006 Featured · Updated 2026-09-26

Ecosystem Pulse

New skills per week

Last 52 weeks
New Claude skills per week, last 52 weeks (source: skill_first_commit_at with repo_created_at fallback)02211442137 new in week of 2025-09-29461 new in week of 2025-10-06506 new in week of 2025-10-13475 new in week of 2025-10-20118 new in week of 2025-10-27325 new in week of 2025-11-03328 new in week of 2025-11-10503 new in week of 2025-11-17264 new in week of 2025-11-24276 new in week of 2025-12-01297 new in week of 2025-12-08692 new in week of 2025-12-15366 new in week of 2025-12-22579 new in week of 2025-12-29876 new in week of 2026-01-051029 new in week of 2026-01-121371 new in week of 2026-01-191332 new in week of 2026-01-261772 new in week of 2026-02-021761 new in week of 2026-02-091837 new in week of 2026-02-161860 new in week of 2026-02-231356 new in week of 2026-03-022069 new in week of 2026-03-092533 new in week of 2026-03-162357 new in week of 2026-03-232053 new in week of 2026-03-301953 new in week of 2026-04-062047 new in week of 2026-04-131996 new in week of 2026-04-202524 new in week of 2026-04-272320 new in week of 2026-05-042183 new in week of 2026-05-113060 new in week of 2026-05-182180 new in week of 2026-05-252491 new in week of 2026-06-012493 new in week of 2026-06-082380 new in week of 2026-06-152671 new in week of 2026-06-222733 new in week of 2026-06-292933 new in week of 2026-07-064421 new in week of 2026-07-133804 new in week of 2026-07-203650 new in week of 2026-07-273152 new in week of 2026-08-034007 new in week of 2026-08-103286 new in week of 2026-08-173162 new in week of 2026-08-243256 new in week of 2026-08-312857 new in week of 2026-09-072494 new in week of 2026-09-141274 new in week of 2026-09-212025-09-292026-09-21

Based on the first commit that touched each skill file. Falls back to the repo's creation date where commit history is unavailable.

Active maintenance

By last push
Active maintenance breakdown — 100060 indexed skills by last repo pushThis week: 50858 (51%)51%This month: 26567 (27%)27%Last 3 months: 22635 (23%)23%This week · 51%This month · 27%Last 3 months · 23%Last 6 months · 0%Stale (6+ months) · 0%

How many indexed skill repos have been pushed to recently. "Stale" means no pushes in 6+ months — still indexed, but not currently maintained.

Top Skills

Showing top 60 of 100,060
Web & Frontend Featured

banner-design

Design banners for social media, ads, website heroes, creative assets, and print. Multiple art direction options with optional generated or supplied visuals. Actions: design, create, generate banner. Platforms: Facebook, Twitter/X, LinkedIn, YouTube, Instagram, Google Display, website hero, print. Styles: minimalist, gradient, bold typography, photo-based, illustrated, geometric, retro, glassmorphism, 3D, neon, duotone, editorial, collage.

130,741 Updated today
nextlevelbuilder
Web & Frontend Featured

design-system

Token architecture, component specifications, and slide generation. Three-layer tokens (primitive→semantic→component), CSS variables, spacing/typography scales, component specs, strategic slide creation. Use for design tokens, systematic design, brand-compliant presentations.

130,741 Updated today
nextlevelbuilder
Web & Frontend Featured

design

Comprehensive design skill: brand identity, design tokens, UI styling, logo generation (55 styles, Gemini, Atlas Cloud, or MuAPI AI), corporate identity program (50 deliverables, CIP mockups), HTML presentations (Chart.js), banner design (22 styles, social/ads/web/print), icon design (15 styles, SVG, Gemini 3.1 Pro), social photos (HTML→screenshot, multi-platform). Actions: design logo, create CIP, generate mockups, build slides, design banner, generate icon, create social photos, social media images, brand identity, design system. Platforms: Facebook, Twitter, LinkedIn, YouTube, Instagram, Pinterest, TikTok, Threads, Google Ads.

130,741 Updated today
nextlevelbuilder
Web & Frontend Featured

ui-styling

Create beautiful, accessible user interfaces with shadcn/ui components (built on Radix UI + Tailwind), Tailwind CSS utility-first styling, and canvas-based visual designs. Use when building user interfaces, implementing design systems, creating responsive layouts, adding accessible components (dialogs, dropdowns, forms, tables), customizing themes and colors, implementing dark mode, generating visual designs and posters, or establishing consistent styling patterns across applications.

130,741 Updated today
nextlevelbuilder
AI & Automation Featured

code-simplifier

Review RTK Rust code for idiomatic simplification. Detects over-engineering, unnecessary allocations, verbose patterns. Applies Rust idioms without changing behavior.

81,747 Updated today
rtk-ai
AI & Automation Featured

design-patterns

Rust design patterns for RTK. Newtype, Builder, RAII, Trait Objects, State Machine. Applied to CLI filter modules. Use when designing new modules or refactoring existing ones.

81,747 Updated today
rtk-ai
AI & Automation Featured

issue-triage

Issue triage: audit open issues, categorize, detect duplicates, cross-ref PRs, risk assessment, post comments. Args: "all" for deep analysis of all, issue numbers to focus (e.g. "42 57"), "en"/"fr" for language, no arg = audit only in French.

81,747 Updated today
rtk-ai
AI & Automation Featured

pr-triage

PR triage: audit open PRs, deep review selected ones, draft and post review comments. Args: "all" to review all, PR numbers to focus (e.g. "42 57"), "en"/"fr" for language, no arg = audit only in French.

81,747 Updated today
rtk-ai
Testing & QA Featured

rtk-tdd

Enforces TDD (Red-Green-Refactor) for Rust development. Auto-triggers on implementation, testing, refactoring, and bug fixing tasks. Provides Rust-idiomatic testing patterns with anyhow/thiserror, cfg(test), and Arrange-Act-Assert workflow.

81,747 Updated today
rtk-ai
AI & Automation Featured

rtk-triage

Triage complet RTK : exécute issue-triage + pr-triage en parallèle, puis croise les données pour détecter doubles couvertures, trous sécurité, P0 sans PR, et conflits internes. Sauvegarde dans claudedocs/RTK-YYYY-MM-DD.md. Args: "en"/"fr" pour la langue (défaut: fr), "save" pour forcer la sauvegarde.

81,747 Updated today
rtk-ai
Testing & QA Featured

tdd-rust

TDD workflow for RTK filter development. Red-Green-Refactor with Rust idioms. Real fixtures, token savings assertions, snapshot tests with insta. Auto-triggers on new filter implementation.

81,747 Updated today
rtk-ai
AI & Automation Featured

career-ops

AI job search command center -- evaluate offers, generate CVs, scan portals, track applications. Use when the user pastes a job URL or JD, asks to scan portals, generate a CV/PDF, track applications, prepare for interviews, draft outreach/emails, or run any career-ops mode.

72,849 Updated today
santifer
AI & Automation Featured

career-ops

AI job search command center -- evaluate offers, generate CVs, scan portals, track applications. Use when the user pastes a job URL or JD, asks to scan portals, generate a CV/PDF, track applications, prepare for interviews, draft outreach/emails, or run any career-ops mode.

72,849 Updated today
career-ops-hq
AI & Automation Featured

last30days

Research what people actually say about any topic in the last 30 days. Pulls posts and engagement from Reddit, X, YouTube, TikTok, Hacker News, Polymarket, GitHub, and the web. Includes a doctor health check to diagnose broken or missing sources.

62,881 Updated 3 days ago
mvanhorn
Code & Development Featured

i-have-adhd

Shape output for a reader with ADHD: lead with the next action, number multi-step work, restate state across turns, suppress tangents, give specific time estimates, make wins visible. Invoke with /i-have-adhd; stays on until "stop adhd mode".

51,299 Updated 6 days ago
ayghri
AI & Automation Featured

adaptyv

How to use the Adaptyv Bio Foundry API and Python SDK for protein experiment design, submission, and results retrieval. Use this skill whenever the user mentions Adaptyv, Foundry API, protein binding assays, protein screening experiments, BLI/SPR assays, thermostability assays, or wants to submit protein sequences for experimental characterization. Also trigger when code imports `adaptyv`, `adaptyv_sdk`, or `FoundryClient`, or references `foundry-api-public.adaptyvbio.com`.

46,700 Updated 5 days ago
K-Dense-AI
AI & Automation Featured

aeon

This skill should be used for time series machine learning tasks including classification, regression, clustering, forecasting, anomaly detection, segmentation, and similarity search. Use when working with temporal data, sequential patterns, or time-indexed observations requiring specialized algorithms beyond standard ML approaches. Particularly suited for univariate and multivariate time series analysis with scikit-learn compatible APIs.

46,700 Updated 5 days ago
K-Dense-AI
Data & Documents Featured

anndata

Data structure for annotated matrices in single-cell analysis. Use when working with .h5ad files or integrating with the scverse ecosystem. This is the data format skill—for analysis workflows use scanpy; for probabilistic models use scvi-tools; for population-scale queries use cellxgene-census.

46,700 Updated 5 days ago
K-Dense-AI
AI & Automation Featured

arbor

Autonomously improve a real artifact (code, training recipe, agent harness, data pipeline, prompt) against an objective and an evaluator, using Hypothesis Tree Refinement (HTR) from the Arbor paper. Use this whenever someone wants to iteratively optimize something over many experiments without overfitting — e.g. "get my model's eval score up", "improve this agent/harness", "tune this pipeline", "beat the baseline on this benchmark", "run a search over approaches and keep the best", "do an MLE-bench / Kaggle-style optimization", or any long-horizon "make this artifact better and don't just memorize the dev set" task. Trigger it even when the user doesn't say "Arbor" or "hypothesis tree" but describes repeated experiment-and-evaluate loops, branching exploration of competing ideas, or worries about a dev/test gap. Runs Claude itself as the coordinator with subagent executors in isolated git worktrees; for the standalone `arbor` CLI tool see references/arbor-upstream.md.

46,700 Updated 5 days ago
K-Dense-AI
AI & Automation Featured

astropy

Core Python library for astronomy and astrophysics workflows that need Astropy APIs, including units/quantities, coordinates, FITS I/O, tables, time systems, WCS, and cosmology. Use when implementing or debugging astronomical data analysis code with Astropy.

46,700 Updated 5 days ago
K-Dense-AI
AI & Automation Featured

autoskill

Observe the user's screen via screenpipe, detect repeated research workflows, match them against existing scientific-agent-skills, and draft new skills (or composition recipes that chain existing ones) for the patterns not yet covered. Use when the user asks to analyze their recent work and propose skills based on what they actually do. Requires the screenpipe daemon (https://github.com/screenpipe/screenpipe) running locally on port 3030 — the skill has no other data source and will refuse to run if screenpipe is unreachable. All detection runs locally; only redacted cluster summaries reach the LLM.

46,700 Updated 5 days ago
K-Dense-AI
AI & Automation Featured

benchling-integration

Benchling Python SDK and REST API integration for registry entities, inventory, ELN entries, workflows, Benchling Apps, and Data Warehouse queries. Use when automating lab data with benchling-sdk or the v2 API.

46,700 Updated 5 days ago
K-Dense-AI
AI & Automation Featured

bgpt-paper-search

Search scientific papers and retrieve structured experimental data extracted from full-text studies via the BGPT MCP server. Returns 25+ fields per paper including methods, results, sample sizes, quality scores, and conclusions. Use for literature reviews, evidence synthesis, and finding experimental details not available in abstracts alone.

46,700 Updated 5 days ago
K-Dense-AI
Data & Documents Featured

biopython

Comprehensive molecular biology toolkit. Use for sequence manipulation, file parsing (FASTA/GenBank/PDB), phylogenetics, and programmatic NCBI/PubMed access (Bio.Entrez). Best for batch processing, custom bioinformatics pipelines, BLAST automation. For quick lookups use gget; for multi-service integration use bioservices.

46,700 Updated 5 days ago
K-Dense-AI
AI & Automation Featured

bioservices

Unified Python interface to 40+ bioinformatics services. Use when querying multiple databases (UniProt, KEGG, ChEMBL, Reactome) in a single workflow with consistent API. Best for cross-database analysis, ID mapping across services. For quick single-database lookups use gget; for sequence/file manipulation use biopython.

46,700 Updated 5 days ago
K-Dense-AI
AI & Automation Featured

cellxgene-census

Query the CZ CELLxGENE Census programmatically for versioned public single-cell and spatial transcriptomics data. Use when you need population-scale cell metadata, gene expression slices, Census summary counts, source H5AD URIs/downloads, embeddings, spatial Census data, or reference atlas comparisons across organisms, tissues, diseases, assays, and cell types. For analyzing your own local single-cell data use scanpy, anndata, or scvi-tools.

46,700 Updated 5 days ago
K-Dense-AI
AI & Automation Featured

cirq

Google quantum computing framework. Use when targeting Google Quantum AI hardware, designing noise-aware circuits, or running quantum characterization experiments. Best for Google hardware, noise modeling, and low-level circuit design. For IBM hardware use qiskit; for quantum ML with autodiff use pennylane; for physics simulations use qutip.

46,700 Updated 5 days ago
K-Dense-AI
Data & Documents Featured

clinical-decision-support

Prepare and validate research-only clinical decision-support evaluation, evidence-profile, cohort, survival, biomarker/model, privacy, and governance artifacts. Use for aggregate or synthetic research documentation and traceability—not patient care or live clinical operation.

46,700 Updated 5 days ago
K-Dense-AI
Data & Documents Featured

clinical-reports

Create safety-bounded draft structures and run local deterministic checks for clinical case, diagnostic, trial, safety, and aggregate research reports. Use only with synthetic, de-identified, or aggregate inputs and verified source-fact manifests; every output requires qualified review.

46,700 Updated 5 days ago
K-Dense-AI
AI & Automation Featured

cobrapy

Constraint-based metabolic modeling (COBRA). FBA, FVA, gene knockouts, flux sampling, SBML models, for systems biology and metabolic engineering analysis.

46,700 Updated 5 days ago
K-Dense-AI
Code & Development Featured

consciousness-council

Run a multi-perspective Mind Council deliberation on any question, decision, or creative challenge. Use this skill whenever the user wants diverse viewpoints, needs help making a tough decision, asks for a council/panel/board discussion, wants to explore a problem from multiple angles, requests devil's advocate analysis, or says things like "what would different experts think about this", "help me think through this from all sides", "council mode", "mind council", or "deliberate on this". Also trigger when the user faces a dilemma, trade-off, or complex choice with no obvious answer.

46,700 Updated 5 days ago
K-Dense-AI
AI & Automation Featured

dask

Distributed computing for larger-than-RAM pandas/NumPy workflows. Use when you need to scale existing pandas/NumPy code beyond memory or across clusters. Best for parallel file processing, distributed ML, integration with existing pandas code. For out-of-core analytics on single machine use vaex; for in-memory speed use polars.

46,700 Updated 5 days ago
K-Dense-AI
API & Backend Featured

database-lookup

Query documented public database APIs with explicit endpoints, filters, pagination, and provenance. Use when a scientific, regulatory, financial, or other database-backed fact must be retrieved reproducibly from a named source rather than inferred from general knowledge.

46,700 Updated 5 days ago
K-Dense-AI
Data & Documents Featured

datamol

Pythonic wrapper around RDKit with simplified interface and sensible defaults. Preferred for standard drug discovery including SMILES parsing, standardization, descriptors, fingerprints, clustering, 3D conformers, parallel processing. Returns native rdkit.Chem.Mol objects. For advanced control or custom parameters, use rdkit directly.

46,700 Updated 5 days ago
K-Dense-AI
AI & Automation Featured

deepchem

Molecular ML with diverse featurizers and pre-built datasets. Use for property prediction (ADMET, toxicity) with traditional ML or GNNs when you want extensive featurization options and MoleculeNet benchmarks. Best for quick experiments with pre-trained models, diverse molecular representations. For graph-first PyTorch workflows use torchdrug; for benchmark datasets use pytdc.

46,700 Updated 5 days ago
K-Dense-AI
Data & Documents Featured

deeptools

NGS analysis toolkit. BAM to bigWig conversion, QC (correlation, PCA, fingerprints), heatmaps/profiles (TSS, peaks), for ChIP-seq, RNA-seq, ATAC-seq visualization.

46,700 Updated 5 days ago
K-Dense-AI
Data & Documents Featured

dhdna-profiler

Extract cognitive patterns and thinking fingerprints from any text. Use this skill when the user wants to analyze how someone thinks, understand cognitive style, profile writing or speech patterns, compare thinking styles between people, asks "what's my thinking style", "analyze how this person reasons", "cognitive profile", "thinking pattern", "DHDNA", "digital DNA", or wants to understand the mind behind any text. Also trigger when the user provides text and wants deeper insight into the author's reasoning patterns, decision-making style, or cognitive signature.

46,700 Updated 5 days ago
K-Dense-AI
Code & Development Featured

diffdock

DiffDock and DiffDock-L molecular docking. Use for protein-small-molecule pose prediction from PDB or sequence plus SMILES/SDF/MOL2, batch docking, virtual screening, and pose-confidence interpretation. Not for binding affinity prediction.

46,700 Updated 5 days ago
K-Dense-AI
AI & Automation Featured

dnanexus-integration

Build and operate reproducible genomics workloads on DNAnexus with the dx CLI, dxpy, apps/applets, native workflows, dxCompiler, and Nextflow. Use for DNAnexus data transfers, dxapp.json development, execution monitoring, workflow import, and project automation.

46,700 Updated 5 days ago
K-Dense-AI
Data & Documents Featured

exa-search

Web toolkit powered by Exa, tuned for scientific and technical content. Use this skill when the user needs to search the web or fetch/extract URL content. Covers: web search (semantic lookups, research, current info — with optional research-paper category and academic domain filtering) and URL extraction (fetching pages, articles, academic PDFs in batch). Use this skill for web-related tasks when the user wants high-quality search or scholarly filtering via category=research paper. Triggers on requests to search, look up, fetch a page, or extract an article.

46,700 Updated 5 days ago
K-Dense-AI
Web & Frontend Featured

experimental-design

Design experiments and studies BEFORE data is collected — choosing a design, randomizing, blocking, and laying out treatment combinations so results are interpretable. Use whenever someone is planning a study, asks how to assign subjects/samples to groups, mentions randomization, blocking, stratification, controls, factorial or fractional-factorial designs, design of experiments (DOE), screening many factors, response-surface optimization, crossover or repeated-measures or split-plot designs, cluster/group randomization, Latin squares, plate layouts, batch/run-order effects, replication vs. pseudoreplication, or sequential/adaptive/group-sequential designs. Trigger even for informal phrasings like "how should I set up this experiment", "how do I avoid confounding", "what's the best way to test these 6 factors", or "assign these mice to conditions". For computing the sample size or power once the design is chosen, use statistical-power; for analyzing data already collected, use statistical-analysis.

46,700 Updated 5 days ago
K-Dense-AI
AI & Automation Featured

generate-image

Generate or edit images with AI models through the OpenRouter Image API (Gemini, Seedream, Recraft, GPT-Image, Riverflow). Use for photos, illustrations, artwork, concept art, visual assets, logos, and image editing or compositing from reference images. For flowcharts, circuits, pathways, and other technical diagrams, use the scientific-schematics skill instead.

46,700 Updated 5 days ago
K-Dense-AI
AI & Automation Featured

gget

Fast CLI/Python queries to 20+ bioinformatics databases. Use for quick lookups: gene info, BLAST/BLAT, viral sequence downloads, AlphaFold structures, enrichment analysis, OpenTargets, COSMIC, CELLxGENE, and 8cube mouse specificity/expression data. Best for interactive exploration and simple queries. For batch processing or advanced BLAST use biopython; for multi-database Python workflows use bioservices.

46,700 Updated 5 days ago
K-Dense-AI
AI & Automation Featured

ginkgo-cloud-lab

Submit and manage protocols on Ginkgo Bioworks Cloud Lab (cloud.ginkgo.bio), a web-based interface for autonomous lab execution on Reconfigurable Automation Carts (RACs). Use when the user wants to run protein expression and purification (cell-free, E. coli, or Pichia), HiBiT or A280 or LabChip quantification, IVT mRNA/circRNA synthesis, thermal shift / developability assays, Echo-MS enzyme or analyte methods, SPR target onboarding, fluorescent pixel art, or otherwise interact with Ginkgo Cloud Lab services. Covers protocol selection, input preparation, pricing, and ordering workflows.

46,700 Updated 5 days ago
K-Dense-AI
Data & Documents Featured

histolab

Lightweight WSI tile extraction and preprocessing. Use for basic slide processing, tissue detection, tile extraction, and stain normalization for H&E images. Best for simple pipelines, dataset preparation, and quick tile-based analysis. For advanced spatial proteomics, multiplexed imaging, or deep learning pipelines use pathml.

46,700 Updated 5 days ago
K-Dense-AI
AI & Automation Featured

hypothesis-generation

Structured hypothesis formulation from observations. Use when you have experimental observations or data and need to formulate testable hypotheses with predictions, propose mechanisms, and design experiments to test them. Follows scientific method framework. For open-ended ideation use scientific-brainstorming; for automated LLM-driven hypothesis testing on datasets use hypogenic.

46,700 Updated 5 days ago
K-Dense-AI
AI & Automation Featured

etetoolkit

Analyze, manipulate, compare, annotate, and visualize phylogenetic or other hierarchical trees with ETE 4. Use for Newick/Nexus tree I/O, topology edits and pattern matching, Robinson-Foulds comparisons, gene-tree evolutionary events and reconciliation, NCBI/GTDB taxonomy, SmartView exploration, and publication rendering. Do not use it to infer trees from raw sequences; align sequences and infer a tree first.

46,700 Updated 5 days ago
K-Dense-AI
Data & Documents Featured

flowio

Read, inspect, and write Flow Cytometry Standard (FCS) 2.0, 3.0, and 3.1 files with FlowIO. Use for low-level FCS metadata and channel inspection, NumPy event extraction, multi-dataset files, table export, and FCS 3.1 creation; use FlowKit for compensation, cytometry transforms, gating, or FlowJo workspaces.

46,700 Updated 5 days ago
K-Dense-AI
AI & Automation Featured

get-available-resources

Detect host inventory and effective CPU, memory, disk, scheduler, container, and accelerator limits when a user asks for resource-aware planning or before a clearly resource-sensitive local workload. Produces a redacted JSON snapshot and conservative planning helpers without stress tests or assuming visible host hardware is usable.

46,700 Updated 5 days ago
K-Dense-AI
Data & Documents Featured

exploratory-data-analysis

Perform bounded, local exploratory analysis of explicitly supported scientific files. Use for redacted CSV/TSV/JSON profiles; optional NumPy, HDF5, FASTA/FASTQ, and basic image metadata inspection; missingness/leakage audits; outlier and transformation sensitivity; and rigorous EDA report scaffolds. Other domain formats are reference-only and unknown formats fail closed.

46,700 Updated 5 days ago
K-Dense-AI
Web & Frontend Featured

fluidsim

Plan, configure, inspect, restart, and analyze bounded FluidSim computational-fluid-dynamics simulations with explicit numerical-validity and HPC safety checks. Use for FluidSim solver selection, parameter review, FFT/MPI setup, output diagnostics, or restart compatibility.

46,700 Updated 5 days ago
K-Dense-AI
AI & Automation Featured

geniml

Use Geniml for audited local genomic-interval workflows: validate BED and universe contracts, plan Region2Vec or scEmbed runs, inspect model/tokenizer compatibility, and assess consensus universes.

46,700 Updated 5 days ago
K-Dense-AI
AI & Automation Featured

geopandas

Guidance and local audit tools for Python workflows that directly use GeoPandas GeoSeries, GeoDataFrame, spatial operations, or vector-data I/O.

46,700 Updated 5 days ago
K-Dense-AI
AI & Automation Featured

gtars

Use Gtars for local genomic interval models and set algebra, overlaps and counts, consensus and coverage, tokenization, fragment processing, and refget/BEDbase planning across Python, Rust, and the CLI.

46,700 Updated 5 days ago
K-Dense-AI
AI & Automation Featured

hypogenic

Plans and audits use of ChicagoHAI HypoGeniC/HypoRefine for LLM-assisted hypothesis generation from labeled text datasets. Use for the `hypogenic` package, its task configs, hypothesis banks, or HypoBench datasets—not for manual hypothesis formulation or scientific validation.

46,700 Updated 5 days ago
K-Dense-AI
AI & Automation Featured

genomic-intelligence

Predict regulatory features, gene structure, and expression directly from DNA sequence using Genomic Intelligence's hosted transformer DNA language models — no local GPU or model weights. Six tasks over a REST API and a hosted MCP server (keyless public demo): promoter regions, splice donor/acceptor sites, enhancer activity, chromatin state, sequence-to-expression (log TPM), and de-novo gene annotation, plus a composite find-genes-then-predict-expression workflow. Use when the user has a gene symbol, a genomic region, or a DNA/FASTA sequence and wants any of these predictions, mentions Genomic Intelligence, genomicintelligence.ai, api.genomicintelligence.ai, or mcp.genomicintelligence.ai.

46,700 Updated 5 days ago
K-Dense-AI
Data & Documents Featured

genomic-coordinates

Convert genomic intervals between coordinate conventions, normalise and compare variant representations, and detect assembly or contig-naming mismatches before they corrupt an analysis. Use whenever coordinates cross a format, tool, or assembly boundary - converting between BED, GFF/GTF, VCF, SAM/BAM, WIG, PSL, genePred, Picard interval_list, or region strings; reconciling 0-based half-open with 1-based inclusive; left-aligning or trimming indels; checking whether two variant records describe the same change; mapping genomic to transcript, CDS, or protein positions; auditing a BED/GTF/VCF for convention violations; or diagnosing GRCh37 vs hg19 vs GRCh38 vs T2T, chr-prefix, and liftover problems. Triggers include "off by one", "0-based", "1-based", "half-open", "coordinate system", "left-align", "normalize variant", "bcftools norm", "chr prefix", "wrong genome build", "liftover", "REF mismatch", and "HGVS".

46,700 Updated 5 days ago
K-Dense-AI
Data & Documents Featured

analytical-method-validation

Plan, execute, and document validation, verification, and transfer of analytical procedures under the governing framework - ICH Q2(R2) and Q14, USP <1220>/<1225>/<1226>, ICH M10 bioanalytical, CLSI EP, or ISO/IEC 17025. Use for HPLC, LC-MS/MS, GC, CE, ICP-MS, dissolution, qNMR, qPCR, NIR, and ligand binding or cell-based assays whenever the question is whether a procedure is fit for its intended purpose. Triggers include "method validation", "analytical method validation", "AMV", "validation protocol", "acceptance criteria", "linearity", "reportable range", "accuracy and precision", "repeatability", "intermediate precision", "recovery", "LOD", "LOQ", "detection limit", "quantitation limit", "specificity", "robustness", "method transfer", "method comparison", "Deming", "Passing-Bablok", "Bland-Altman", "equivalence testing", "OOS investigation", "ICH Q2", "Q2(R2)", "Q14", "USP 1225", "ICH M10", "incurred sample reanalysis", "ISR", "CLSI EP", and any request to show that an assay works.

46,700 Updated 5 days ago
K-Dense-AI
Code & Development Featured

deepspot-m

Generate transcriptome-wide virtual spatial transcriptomics from H&E histology with DeepSpot-M. Use when you need spatial gene expression in log1p-CPM for 224x224 tiles at about 20x, want to query protein-coding genes by symbol instead of a fixed panel, or want to run prediction across a whole slide after tiling with histolab.

46,700 Updated 5 days ago
K-Dense-AI
Data & Documents Featured

datalad

Retrieve, version, and publish scientific datasets with DataLad and git-annex, and capture computational provenance with datalad run, rerun, and containers-run. Use when cloning or fetching data from OpenNeuro, DANDI, datasets.datalad.org, or any DataLad dataset; when a file in a dataset reads as a broken symlink or a small pointer instead of real data; when an analysis needs a machine-readable record of how each output was produced so it can be re-executed; or when publishing a dataset to siblings such as a GitHub repository plus a storage remote. Also use to decide between DataLad and plain Git for a data-carrying repository.

46,700 Updated 5 days ago
K-Dense-AI