← ClaudeAtlas

gocam-curationlisted

Evaluate and review GO-CAM (Gene Ontology Causal Activity Model) activities / annotons — molecular-function typing, has-input, causal relations, complexes, evidence — and check their consistency with gene annotation reviews. Use when reviewing cached GO-CAMs under gocams/, filling a GoCamReview YAML (gocams/<id>/<id>-review.yaml), or grounding a module in GO-CAM models.
ai4curation/ai-gene-review · ★ 23 · AI & Automation · score 74
Install: claude install-skill ai4curation/ai-gene-review
# GO-CAM curation & review Use this skill to **read and assess** GO-CAM models. This project is read-only: we never edit or upload models. We cache them (`gocams/<id>/<id>-src.yaml`), index their activities (`gocams/index.tsv`), and record assessments in `gocams/<id>/<id>-review.yaml` (schema class `GoCamReview`). ## What an activity (annoton) is Each GO-CAM activity couples: - `enabled_by` — the **gene product** carrying the activity; - `molecular_function` — the GO MF term; - `part_of` — optional **biological process** it contributes to; - `occurs_in` — optional **cellular component** it happens in; - `causal_associations` — directed edges to **downstream** activities. In the cached YAML these are fields of each entry under `activities:`; they are flattened one-row-per-activity into `gocams/index.tsv` (join key: `gene_product`). ## How to evaluate an activity For each activity, work through these and record the outcome in the `GoCamActivityReview`: 1. **Molecular function** — most specific correct term; not a bare `binding` term; the real role (catalytic / receptor / adaptor / sequestering). → `references/molecular-function.md` 2. **`has input`** — names the substrate / target-gene / effector / cargo, not a ligand or raw DNA. → `references/has-input.md` 3. **Causal edges** — direct vs indirect, subject→object directionality, mechanism vs phenotype. → `references/causal-relations.md` 4. **Complexes** — right active subunit vs complex term. → `reference