reconcile-cross-document-facts

# Cross-Document Fact Reconciliation Maintain a register of the clinical pharmacology values and claims that travel along a programme's document thread — protocol, CSR, Module 2.7.2, briefing documents, health-authority responses, label — and reconcile each new or revised document against a baselined source-version record. Produce a register in which every fact carries its origin, every restatement carries its locator, and every conflict carries both sides — for a qualified clinical pharmacologist to disposition. **This skill reconciles and traces. It never edits a document, reruns an analysis, or decides which of two conflicting values is correct.** ## Who this is for Clinical pharmacology leads holding a programme's numbers together across studies · regulatory-facing CP reviewers preparing a submission or a meeting package · document owners who need to know what a changed source value breaks downstream. ## When to use this skill Use when the object is the **thread**, not a single document — several documents, often several studies, usually several versions in time: - "Reconcile the dose rationale across protocol, CSR, 2.7.2 and label" - "Does the clearance in the proposed label still match the CSR it came from?" - "We reran the NCA on Study 102 — what downstream documents restate those values?" - "Track every place we have stated the food-effect result, and when we stated it" - "Before this briefing package goes out, check nothing contradicts what we already told the...