dls-particle-sizer

# DLS Particle Sizer ## Purpose The DLS Particle Sizer skill provides dynamic light scattering analysis for nanoparticle hydrodynamic size determination, enabling rapid, non-destructive measurement of size distributions and stability assessment. ## Capabilities - Hydrodynamic diameter measurement - Polydispersity index (PDI) calculation - Size distribution analysis (intensity, volume, number) - Temperature-dependent measurements - Multi-angle DLS analysis - Particle concentration estimation ## Usage Guidelines ### DLS Measurement 1. **Sample Preparation** - Dilute to appropriate concentration - Filter to remove dust - Equilibrate temperature 2. **Data Analysis** - Use cumulants for monomodal samples - Apply CONTIN for multimodal - Report intensity-weighted Z-average 3. **Quality Metrics** - PDI < 0.1: Monodisperse - PDI 0.1-0.3: Narrow distribution - PDI > 0.3: Broad distribution ## Process Integration - Statistical Particle Size Distribution Analysis - Nanoparticle Synthesis Protocol Development - Nanoparticle Drug Delivery System Development ## Input Schema ```json { "sample_id": "string", "solvent": "string", "temperature": "number (C)", "refractive_index": "number", "viscosity": "number (cP)" } ``` ## Output Schema ```json { "z_average": "number (nm)", "pdi": "number", "distribution": { "intensity": {"peaks": [{"size": "number", "percent": "number"}]}, "volume": {"peaks": [{"size": "number", "percent": "num...