hpo-phenotype-matcher

# HPO Phenotype Matcher Skill ## Purpose Provide Human Phenotype Ontology capabilities for phenotype-driven gene prioritization. ## Capabilities - HPO term matching - Gene-phenotype association scoring - Semantic similarity analysis - Phenotype-variant correlation - Exomiser integration - Prioritization reporting ## Usage Guidelines - Map clinical phenotypes to HPO terms - Calculate gene-phenotype associations - Use semantic similarity for ranking - Integrate with variant prioritization - Generate prioritization reports - Document phenotype encoding ## Dependencies - HPO - Exomiser - Phen2Gene ## Process Integration - Rare Disease Diagnostic Pipeline (rare-disease-diagnostics) - Clinical Variant Interpretation (clinical-variant-interpretation)