ligand-exchange-protocol-manager

# Ligand Exchange Protocol Manager ## Purpose The Ligand Exchange Protocol Manager skill provides systematic management of surface functionalization reactions for nanoparticles, enabling controlled ligand exchange, bioconjugation, and quantification of surface functional groups. ## Capabilities - Ligand exchange reaction design - Bioconjugation chemistry selection - Click chemistry protocols - Functional group quantification (TNBS, Ellman's) - Conjugation efficiency optimization - Surface coverage calculation ## Usage Guidelines ### Ligand Exchange Design 1. **Chemistry Selection** - Match incoming ligand affinity - Consider exchange kinetics - Optimize solvent system 2. **Bioconjugation Protocols** - EDC/NHS for carboxyl-amine coupling - Maleimide-thiol for cysteine targeting - Click chemistry for orthogonal conjugation 3. **Surface Coverage Quantification** - UV-Vis for chromophoric ligands - TGA for organic content - XPS for elemental analysis ## Process Integration - Nanomaterial Surface Functionalization Pipeline - Nanoparticle Drug Delivery System Development - Nanosensor Development and Validation Pipeline ## Input Schema ```json { "nanoparticle_type": "string", "current_ligand": "string", "target_ligand": "string", "target_functionality": "amine|carboxyl|thiol|azide|alkyne", "conjugation_target": "string (optional)" } ``` ## Output Schema ```json { "exchange_protocol": { "solvent": "string", "temperature": ...