pharmgkb-annotator

# PharmGKB Annotator Skill ## Purpose Provide PharmGKB pharmacogenomics annotation for drug-gene interaction assessment. ## Capabilities - Star allele calling (Stargazer) - Diplotype determination - CPIC guideline integration - Drug recommendation generation - Clinical annotation lookup - Dosing guidance extraction ## Usage Guidelines - Call star alleles accurately - Determine diplotypes from genotypes - Apply CPIC guidelines for dosing - Generate actionable recommendations - Review clinical annotations - Document guideline versions ## Dependencies - PharmGKB API - Stargazer - PharmCAT ## Process Integration - Pharmacogenomics Analysis (pharmacogenomics-analysis) - Clinical Variant Interpretation (clinical-variant-interpretation)