pipeline-vaccines

> Methodology inspired by publicly taught vaccine development frameworks; all text is an original paraphrase. ## Defaults | Parameter | Default Value | Rationale | |-----------|---------------|-----------| | asset_scope | all disclosed vaccine assets | Full-pipeline enumeration first | | evidence_lens | immunogenicity + efficacy | Correlate studies distinguished from efficacy trials | | acip_gate | true | ACIP path modeled as part of pipeline value | | cohort_lens | true | Age-cohort bridging tracked per asset | | value_frame | risk-adjusted | Modeled value = unadjusted peak x POS, both shown | ## Preflight Run canonical pre-flight per `contracts/preflight.md`. Include the `X-Agentii-Trace` header on every tool call per `contracts/x-agentii-trace-header.md` — carry the `_run_id` from your first tool result and name yourself (and your parent, if you were spawned). Confirm ticker resolution via `search_companies` before asset queries. ## Triggers - "Analyze [ticker]'s vaccine pipeline." - "What seroconversion or immunogenicity studies support [vaccine]?" - "Where are [ticker]'s vaccines in the efficacy ladder?" - "Which lot-consistency trials are pending for [ticker]?" - "What age-cohort bridging studies does [ticker] have planned?" - "Does [ticker]'s vaccine have an ACIP path?" - "Risk-adjust [ticker]'s vaccine pipeline." - "What is the next catalyst for each of [ticker]'s vaccine assets?" - "How do healthy-population efficacy designs change the evidence bar?" - "Map [ti...