clinpgx-database

# ClinPGx Database ## Overview ClinPGx (Clinical Pharmacogenomics Database) is a comprehensive resource for clinical pharmacogenomics information, successor to PharmGKB. It consolidates data from PharmGKB, CPIC, and PharmCAT, providing curated information on how genetic variation affects medication response. Access gene-drug pairs, clinical guidelines, allele functions, and drug labels for precision medicine applications. ## When to Use This Skill This skill should be used when: - **Gene-drug interactions**: Querying how genetic variants affect drug metabolism, efficacy, or toxicity - **CPIC guidelines**: Accessing evidence-based clinical practice guidelines for pharmacogenetics - **Allele information**: Retrieving allele function, frequency, and phenotype data - **Drug labels**: Exploring FDA and other regulatory pharmacogenomic drug labeling - **Pharmacogenomic annotations**: Accessing curated literature on gene-drug-disease relationships - **Clinical decision support**: Using PharmDOG tool for phenoconversion and custom genotype interpretation - **Precision medicine**: Implementing pharmacogenomic testing in clinical practice - **Drug metabolism**: Understanding CYP450 and other pharmacogene functions - **Personalized dosing**: Finding genotype-guided dosing recommendations - **Adverse drug reactions**: Identifying genetic risk factors for drug toxicity ## Installation and Setup ### Python API Access The ClinPGx REST API provides programmatic access to all database...