review-adc-analyte-strategy

# ADC Analyte Strategy Review Check whether an antibody-drug conjugate's analyte set is defined consistently, measured where the programme's questions require it, and reported without internal contradiction across documents. Produce an analyte definition register, a question-to-analyte coverage matrix and a cross-analyte consistency table — for a qualified clinical pharmacologist to disposition. > **The recurring failure in ADC programmes is not a wrong number. It is the same > word meaning different things in different documents.** > > "Total antibody", "conjugated antibody", "ADC", "total payload", "free > payload" — these are defined per programme, and a protocol, a bioanalytical > plan and a CSR can each use one of them differently while every individual > document reads correctly. This skill compares the definitions. ## Why this is its own package The nearest neighbour is `review-csr-pk-consistency`, which compares one value against its source. This is a different shape: the risk is that **two documents agree numerically while disagreeing about what was measured**. Applying the six separability tests, four pass — distinct trigger (an ADC or multi-analyte question), distinct inputs (an analyte definition table and a bioanalytical plan), distinct neighbours (payload toxicology, DAR characterisation), distinct evolution (modality guidance moves independently). Merging requires all six to fail. ## Who this is for Clinical pharmacologists on ADC or multi-analyte progra...